Bacteriophages armed with silver nanoparticles

06 02 2023

On Monday 20th of February at 2 pm, Dr. Piotr Golec from the Department of Molecular Virology will give a seminar entitled ‘An effective antibiofilm strategy based on bacteriophages armed with silver nanoparticles‘.

Abstract:

In this presentation, I will show that T7 phages armed with silver nanoparticles exhibit greater efficacy in terms of controlling bacterial biofilm, compared with phages or nanoparticles alone. We initially identified a novel silver nanoparticle-binding peptide, then constructed T7 phages that successfully displayed the peptide on the outer surface of the viral head. These recombinant phages could effectively eradicate bacterial biofilm, even when used at low concentrations. Our results show that the novel combination of phages with silver nanoparticles is an effective and safe strategy for the treatment of bacterial biofilms.