Iron homeostasis in the enteropathogen Yersinia enterocolitica

24 05 2021

Today, during the seminar, MSc Karolina Jaworska from the Department of Molecular Microbiology will give a talk about “Impact of the regulator OmpR on iron homeostasis in the enteropathogen Yersinia enterocolitica“.

Differential proteomic analyzes of the outer membrane of Y. enterocolitica 2/O:9 showed the effect of OmpR, a response regulator in the EnvZ/OmpR two-component signal transduction system, on the synthesis of iron/heme receptors. The main regulator of iron homeostasis in Y. enterocolitica is the Fur repressor. The conducted research revealed previously unknown connection between the functioning of the OmpR regulator and iron homeostasis, necessary for the survival of bacteria in ecological niches characterized by variable iron content. By controlling the Fur repressor level and its activity, as well as the functioning of iron transport systems, OmpR can provide the optimal amount of iron for cellular metabolism while preventing its toxic accumulation.

You are welcome to join us, although the seminar will be held in Polish!

The seminar will be held online via Zoom application at 14:00. If you’re interested in receiving an invitation, send an e-mail about that at seminariumim@uw.edu.pl.